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Residual HIV Replication and Therapy Intensification

Upon Raltegravir intensification, nascent viral genomes are prevented from integrating and are subsequently converted to episomes. The increase in episomal cDNA following Raltegravir intensification requires the presence of infectious virus and also requires de novo infection and reverse transcription: which together, strongly suggest that active viral replication persists in HAART.

Autor und Referent

Dr. Javier Martinez-Picado

Dr. Javier Martinez Picado is ICREA Research Professor at IRSICAIXA (IrsiCaixa).

 

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