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Integrase Inhibitors, From Drug Discovery to Clinical Practice

Beschreibung

Integrase strand transfer inhibitors (InSTIs) present a novel mechanism without cross resistance to other, licensed ARVs.
The mechanism of InSTI resistance explains the substantial cross resistance observed among diverse InSTIs.
InSTIs exhibit a prolonged window for intervention and a long intracellular residence time. These have implications for understanding PK/PD and for potential use in PREP and PEP?

Autor und Referent

Dr. Daria Hazuda

Dr. Hazuda is Vice-President; Worldwide Basic Research Head for Antivirals
at the Merck Research Labs.

 

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